brain function — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T60080	TMPH	2,2,6,6-Tetramethylpiperidin-4-yl heptanoate	AChR
	TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.		AChR
T12492	Pivagabine	CXB-722	GABA Receptor
	Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor...		GABA Receptor
T3597	Cutamesine dihydrochloride	AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride	Sigma receptor
	Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitr...		Sigma receptor
T9232	Mitochondrial fusion promoter M1		Mitochondrial Metabolism
	Mitochondrial fusion promoter M1, a modulator of mitochondrial dynamics, enhances mitochondrial function and cellular respiration, and has shown efficacy in reducing brain and cardiac damage in rats suffering from cardia...		Mitochondrial Metabolism
T50047	1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride		Others
	1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride is a cholinergic agent that inhibits choline metabolism, which leads to increased levels of acetylcholine in the brain, which in turn enhances cognitive ...		Others
T6961	PX-478	PX-478 2HCl	HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
	PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di...		HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
T50064	2-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate		KLF
	2-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate is a pro-neurotropic drug used to enhance cognitive function by increasing the synthesis and release of acetylcholine in the brain as well as by inhibiting the br...		KLF
T4947	3-Hydroxybutyric acid	Butanoic acid	Endogenous Metabolite
	3-Hydroxybutyric acid (Butanoic acid) (or beta-hydroxybutyrate) is a ketone body. Like the other ketone bodies (acetoacetate and acetone), levels of 3-hydroxybutyrate in blood and urine are raised in ketosis. In humans, ...		Endogenous Metabolite
T0869	Atomoxetine hydrochloride	Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,LY 139603,Atomoxetine HCl,LY 139603 HCl	Dopamine Receptor , 5-HT Receptor , Norepinephrine
	Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Althou...		Dopamine Receptor , 5-HT Receptor , Norepinephrine
T75389	Catechol O-methyltransferase
	Catechol O-methyltransferase (COMT) is a magnesium-dependent enzyme that mediates the transfer of methyl groups from S-adenosyl methionine to the hydroxyl group on dopamine, thus converting it to 3-methoxytyramine. COMT ...
T3893	Forsythoside B		TNF , NF-κB
	Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effect...		TNF , NF-κB
T38063	N-Acetyl lysyltyrosylcysteine amide		Glutathione Peroxidase
	N-Acetyl lysyltyrosylcysteine amide is a non-toxic myeloperoxidase (MPO) tripeptide inhibitor that is potent, reversible, and specific.N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO production in vivo. N-Ac...		Glutathione Peroxidase
T12945	SNT-207858 free base		Others
	SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor).		Others
T12946	SNT-207858		Others
	SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.		Others
T68257	Hydromethylthionine HBr
	Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacologi...
T74045	H-Lys-Tyr-OH TFA
	Lysyltyrosine TFA (H-Lys-Tyr-OH TFA) is a dipeptide consisting of lysine and tyrosine. It enhances brain function or mitigates neurological diseases by facilitating the release of noradrenaline and tyrosine into the brai...
T77995	NNZ 2591
	NNZ 2591, a synthetic analogue of cyclic glycine-proline (cGP), exhibits oral activity and the ability to cross the blood-brain barrier. This compound demonstrates neuroprotective properties following ischemic brain inju...
T60344	L-Cytidine
	L-Cytidine is an L-configurational form of Cytidine. L-Cytidine is a pyrimidine nucleoside which is a component of RNA. Cytidine can control the glial glutamate cycle, and affect brain phospholipid metabolism, catecholam...
T62640	FPR2 agonist 2
	FPR2 agonist 2 is a potent FPR2 agonist with blood-brain barrier permeability that acts on h-FPR2 (EC50: 0.13 nM). fPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counteracts changes in mitochondria...
T79172	PF-06655075		Oxytocin Receptor
	PF-06655075 is a novel, non-brain-penetrant oxytocin receptor agonist that demonstrates enhanced selectivity for the oxytocin receptor and substantially improved pharmacokinetic stability. This compound serves as a tool ...		Oxytocin Receptor